Interleukin-21 receptor binding proteins

Details Interleukin-21 receptor binding proteins Interleukin-21 receptor binding proteins

C - Chemistry, Metallurgy

07

K

C07K 14/715 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2724915

The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing and/or treating IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.

Linvention concerne des protéines de liaison et ses fragments de liaison à un antigène qui se lient spécifiquement au récepteur dinterleukine-21 humain (IL-21R). Les protéines de liaison peuvent agir, par exemple, comme des antagonistes de lactivité dIL-21R, modulant ainsi les réponses immunitaires en général, et celles véhiculées par IL-21R en particulier. Les compositions et procédés décrits peuvent être utilisés, par exemple, dans le diagnostic et/ou le traitement de troubles associés à IL-21R, par exemple des troubles inflammatoires, des maladies auto-immunitaires, des allergies, le rejet de greffe, un cancer et dautres troubles du système immunitaire.

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