Interleukin-3 (il-3) multiple mutation polypeptides

Details Interleukin-3 (il-3) multiple mutation polypeptides Interleukin-3 (il-3) multiple mutation polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2150116

The present invention relates to a recombinant human interleukin-3(hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequence encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids 119 to 133 have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide. These hIL-3 multiple mutation polypeptides may have biological activities similar to or better than hIL-3 and, in some cases, may also have an improved side effect profile.

Affiliated with

Also associated with

Rating

Interleukin-3 (il-3) multiple mutation polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Interleukin-3 (il-3) multiple mutation polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interleukin-3 (il-3) multiple mutation polypeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1366326