Interleukin 4 signal transducers and binding assays

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/24 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/54 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2153180

The invention provides methods and compositions for identifying pharmacological agents useful in the diagnosis or treatment of disease associated with the expression of a gene modulated by an interleukin 4 signal transducer and activator of transcription, IL-4 Stat. IL-4 Stat peptides and IL-4 receptor peptides and nucleic acids encoding such peptides find therapeutic uses. The subject compositions include IL-4 Stat and IL-4 receptor proteins, portions thereof, nucleic acids encoding them, and specific antibodies. The disclosed pharmaceutical screening methods are particularly suited to high-throughput screening where one or more steps are performed by a computer controlled electromechanical robot comprising an axial rotatable arm.

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