C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/10 (2006.01) A61K 31/53 (2006.01) A61K 51/04 (2006.01) A61P 11/06 (2006.01) C07D 413/10 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2380759
The present invention relates to IL-5 inhibiting 6-azauracil derivatives of formula (I) useful for treating eosinophil- dependent inflammatory diseases, to processes and intermediates for their preparation as well as to pharmaceutical compositions comprising the said derivatives. It further relates to the use of such derivatives as a medicine, and to processes for marking a receptor or imaging an organ using the said derivatives.
L'invention concerne des dérivés de 6-azauracile utilisés comme inhibiteurs d'IL-5 de formule (I) pour le traitement de maladies inflammatoires dépendant des éosinophiles. Elle concerne également des procédés et intermédiaires destinés à leur préparation ainsi que des compositions pharmaceutiques renfermant lesdits dérivés. Elle traite enfin de l'utilisation de ces dérivés comme médicament, ainsi que de procédés permettant de marquer un récepteur ou de produire une image d'un organe utilisant lesdits dérivés.
Coesemans Erwin
Deroose Frederik Dirk
Fortin Jerome Michel Claude
Freyne Eddy Jean Edgard
Lacrampe Jean Fernand Armand
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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