C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/08 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2196878
Object: to provide an erythromycin derivative having a potent interleukin-5 production inhibitory effect. Constitution: an interleukin-5 production inhibitor containing as the active ingredient an erythromycin derivative, such as 6-O-methylerythromycin A 9-[O-(2-chlorophenylmethyl)oxime], 6-O- methylerythromycin A 9-[O-(3-methoxy-4-t-butylbenzyl)oxime] 11,12-cyclic carbonate or 11-amino-9-N, 11-N-cyclic ethylene-9-deoxo-11-deoxy-6-O- methylerythromycin A 9-benzylamine 11-N, 12-O-cyclic carbamate, or a medicinally acceptable acid-addition salt thereof.
Un dérivé de l'érythromycine présente un puissant effet inhibiteur de la production d'interleukine-5. Ce dérivé d'érythromycine, ingrédient actif de l'inhibiteur de production d'interleukine-5, peut être 6-O-méthylérythromycine A 9-[O-(2-chlorophénylméthyl)oxyme], carbonate de 6-O-méthylérythromycine A 9-[O-(3-méthoxy-4-t-butylbenzyl)oxyme] 11,12-cyclique ou 11-amino-9-N, 11-N-cyclique éthylène-9-déoxo-11-déoxy-6-O-méthylérythromycine A 9-benzylamine 11-N, carbamate 12-O-cyclique, ou l'un de leurs sels d'addition d'acide médicalement acceptable.
Asaka Toshifumi
Hoshino Akihiko
Inoue Tomoyuki
Kashimura Masato
Okudaira Hirokazu
Mccarthy Tetrault Llp
Taisho Pharmaceutical Co. Ltd.
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