Interleukin-6 compositions, and a production process thereof

Details Interleukin-6 compositions, and a production process thereof Interleukin-6 compositions, and a production process thereof

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2085744

ABSTRACT The present invention relates to compositions containing human interleukin-6 with sugar chains, a process for preparing human interleukin-6 by culturing cells in a medium containing ascorbic acid or any of its derivatives, and a process for purifying a crude raw human interleukin-6 solution by chromatography using a carrier with heparin bound. The present invention has allowed the production of high quality human interleukin-6 compositions with sugar chains, and their application to medicines. Furthermore, it has established a process for massproducing human interleukin-6. 18

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