Intermediate compounds for the preparation of mirtazapine...

Details Intermediate compounds for the preparation of mirtazapine... Intermediate compounds for the preparation of mirtazapine...

C - Chemistry, Metallurgy

07

C

C07C 233/11 (2006.01) C07C 231/02 (2006.01) C07C 237/22 (2006.01) C07D 241/04 (2006.01)

Patent

CA 2460571

The invention relates to intermediate compounds that are used for the preparation of mirtazapine and the production methods thereof. The inventive method is used to produce (+/-)-3-phenyl-1-methylpiperazine which is an important intermediate for the production of mirtazapine. Said method consists in subjecting novel compounds having general formula (I), wherein Z is a leaving group that can undergo nucleophilic displacement, to a cyclization reaction in the presence of a reducing agent. The invention also relates to a method of producing novel compounds having formula (I).

L'invention concerne des composés intermédiaires pour la préparation de mirtazapine et leurs procédés de production. L'invention décrit un procédé de production de (+/-)-3-phényl-1-méthyltilpiperazine, intermédiaire important pour la production de mirtazapine. Ce procédé de production consiste à soumettre de nouveaux composés représentés par la formule générale (I) à une réaction de cyclage, en présence d'un réducteur. Dans cette formule générale, Z représente un groupe partant capable de subir un déplacement nucléophile. L'invention concerne également un procédé permettant de produire les nouveaux composés représentés par la formule générale (I).

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