Intermediate compounds for the preparation of statins

Details Intermediate compounds for the preparation of statins Intermediate compounds for the preparation of statins

C - Chemistry, Metallurgy

07

C

C07C 229/30 (2006.01) C07D 207/34 (2006.01)

Patent

CA 2630507

Process for the preparation of statins, in particular atorvastatin via intermediates of Formula (1) and a process for the preparation of said intermediates.

L~invention concerne un procédé de préparation de composés intermédiaires utilisés pour préparer des statines. Ce procédé est particulièrement utile pour préparer l~atorvastatine. Le procédé implique la réduction simultanée de deux groupes cétone au moyen d~un catalyseur chiral à base de métal de transition, ou d~un système à base d~enzymes.

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