Intermediate in production of...

Details Intermediate in production of... Intermediate in production of...

C - Chemistry, Metallurgy

07

C

C07C 211/45 (2006.01) C07C 233/25 (2006.01) C07C 275/32 (2006.01) C07D 295/02 (2006.01)

Patent

CA 2609255

A compound represented by the general formula below or a salt thereof is a useful intermediate in the production of a [2-(3,3,5,5- tetramethylcyclohexyl)phenyl]piperazine compound that has excellent cell adhesion inhibitory effect and cell invasion inhibitory effect and therefore is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases induced by the adhesion and invasion of leukocytes, such as inflammatory bowel diseases (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. [Chemical formulae] wherein R1 and R2 independently represent a hydrogen atom or an amino-protecting group for an amino group, or R1 and R2 may together form a pyrrole ring which may have a substituent.

L~invention concerne un composé représenté par la formule générale ci-dessous ou un sel de celui-ci comme intermédiaire utile dans la production d'un composé de [2-(3,3,5,5-tétraméthylcyclohexyl)phényl]pipérazine qui a un excellent effet d'inhibition de l'adhésion de cellules et un excellent effet d'inhibition de l'invasion de cellules et par conséquent qui est utile comme agent thérapeutique ou prophylactique pour différentes maladies inflammatoires et maladies auto-immunes induites par l'adhésion et l'invasion de leucocytes, telles que des affections abdominales inflammatoires (en particulier la rectocolite hémorragique ou la maladie de Crohn), le syndrome du côlon irritable, la polyarthrite rhumatoïde, le psoriasis, la sclérose en plaques, l'asthme et la dermatite atopique. [Formule chimique] dans laquelle R1 et R2 représentent indépendamment un atome d'hydrogène ou un groupe protecteur de groupe amino ou bien R1 et R2 peuvent former ensemble un cycle pyrrole lequel peut avoir un substituant.

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