Intermediates and a process employing the intermediates for...

Details Intermediates and a process employing the intermediates for... Intermediates and a process employing the intermediates for...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07C 317/44 (2006.01)

Patent

CA 2716767

This invention relates to a process for the preparation of (3- trifluoromethylsulfonyl)-N-[4-methyl-3-(4- pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide (formula (I)) starting from 4-methyl-2-nitro-aniline (formula (II)) through intermediates (3- trifiuoromethylsulfonyl)-N-[4-methyl-3-nitrophenyl]- benzamide (formula (III)), (3- trifluoromethylsulfonyl)-N-[3- amino-4-methylphenyl]-benzamide (formula (IV)) and (3- trifluoromethylsulfonyl)-N-[3-guanidino-4-methylphenyl]-benzamide (formula (V)). This invention also relates to processes for the preparation of these intermediates. The compound of formula (I), also known as AN-024, is: (I).

Cette invention concerne un procédé de préparation de (3-trifluorométhylsulfonyl)-N-[4- méthyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phényl]-benzamide (formule (I)) à partir de 4-méthyl-2-nitro-aniline (formule (II)) au moyen d'intermédiaires (3- trifiuorométhylsulfonyl)-N-[4-méthyl-3-nitrophényl]-benzamide (formula (III)), (3- trifluorométhylsulfonyl)-N-[3-amino-4-méthylphényl]-benzamide (formule (IV)) et (3- trifluorométhylsulfonyl)-N-[3-guanidino-4-méthylphenyl]-benzamide (formule (V)). Cette invention concerne également des procédés de préparation de ces intermédiaires. Le composé de formule (I) est également connu sous le nom de AN-024.

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