Intermediates and process for the preparation of aromatic...

Details Intermediates and process for the preparation of aromatic... Intermediates and process for the preparation of aromatic...

C - Chemistry, Metallurgy

07

C

C07C 51/08 (2006.01) C07C 43/23 (2006.01) C07C 255/54 (2006.01) C07C 309/65 (2006.01)

Patent

CA 2631698

Process for the preparation of aromatic derivatives of 1 -adamantane (tricyclo[3.3.1.1 (3,7)]decane), or an acceptable pharmaceutical salt thereof, based on a hydrolysis reaction of a precursor cyano compound. It also comprises different processes for obtaining the cyano compound. It is especially useful for obtaining Adapalene on an industrial scale in high yield and purity. It also comprises new intermediates useful in said preparation process.

L'invention concerne un procédé de préparation de dérivés aromatiques de 1 -adamantane (tricyclo[3.3.1.1 (3,7)]décane) ou d'un sel de qualité pharmaceutique de ceux-ci, basé sur une réaction d'hydrolyse d'un composé cyano précurseur. L'invention concerne également divers procédés permettant d'obtenir le composé cyano. Le procédé selon l'invention est spécialement utile pour obtenir l'adapalène à une échelle industrielle, avec un rendement élevé et une pureté élevée. L'invention concerne également de nouveaux intermédiaires utiles dans le procédé de préparation selon l'invention.

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