Intermediates for 9-deazaguanines

Details Intermediates for 9-deazaguanines Intermediates for 9-deazaguanines

C - Chemistry, Metallurgy

07

D

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C07D 239/46 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 487/04 (2006.01)

Patent

CA 1320203

ABSTRACT Intermediates for novel derivatives of pyrrolo[3,2-d]pyrimidines. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation. The intermediates have the general formulae: Image Image or wherein R2 is hydrogen or NH2, and Ar is (i) phenyl unsubstituted or substituted by halogen, alkyl of from one to four carbon atoms, hydroxy, alkoxy of one to four carbon atoms, or trifluoromethyl; (ii) 2- or 3- thienyl; or (iii) 2- or 3-furanyl.

616019

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