C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/244.2, 260/3
C07D 498/04 (2006.01) C07D 205/08 (2006.01) C07F 9/65 (1980.01)
Patent
CA 1182453
ABSTRACT OF THE DISCLOSURE Intermediates are provided for preparing cephalosporin analogues having antimicrobial activity; the intermediates have the formula Image (Ib) wherein R2 is carboxy or a protected carboxy, and Y is hydrogen or lower alkoxy, or a salt thereof, which comprises subjecting a compound of the formula: Image (Ia) wherein R1a is acyl selected from the groups consisting of ar(lower)alkanoyl which may have a sulfo group, aryloxy- (lower)alkanoyl which may have suitable substituent(s), lower alkanoyl substituted with an unsaturated 3 to 8-membered heteromonocyclic group containing 1 to 4 nitrogen atom(s) which may have suitable substituent(s), lower alkanoyl substituted with an unsaturated 3 to 8-membered heteromonocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s) which may have suitable substituent(s), and a group or the formula: R3-A-CO- in which R3 is aryl or a heterocyclic group which may have suitable substituent(s) and A is carbonyl, hydroxyimino(lower)- alkylene, lower alkoxyimino(lower)alkylene, lower alkenyl- oxyimino(lower)alkylene, lower alkynyloxyimino(lower)- alkylene, cyclo(lower)alkoxyimino(lower)alkylene or ar- (lower)alkoxyimino(lower)alkylene; R2 is carboxy or a protected carboxy, and Y is hydrogen or lower alkoxy, or a salt thereof, to deacylation reaction.
380532
Aratani Matsuhiko
Hagiwara Daijiro
Hashimoto Masashi
Hemmi Keiji
Takeno Hidekazu
Fujisawa Pharmaceutical Co. Ltd.
Marcoux & Sher Swabey Mitchell Houle
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