Intermediates for polycyclic quinonoid antibiotics

C - Chemistry – Metallurgy – 07 – C

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C07C 237/26 (2006.01) C07C 46/00 (2006.01) C07C 46/02 (2006.01) C07C 46/06 (2006.01)

Patent

CA 1097342

RC 3.0-126 INTERMEDIATES FOR POLYCYCLIC QUINONOID ANTIBIOTICS ANDREW S. KENDE YUH-GENG TSAY JOHN E. MILLS ABSTRACT OF THE DISCLOSURE There is provided a novel method of synthesizing certain tetracyclic quinones. In particular, there is pro- vided a novel route to the synthesis of (?)-7-deoxydauno- mycinone and analogs thereof, which includes the provision of novel tri- and tetracyclic quinone intermediates. The -7- deoxydaunomycinone derived from naturally occurring dauno- mycin is a known compound, which is itself an intermediate in the preparation of the clinically accepted anti-tumor antibiotics daunomycine and its derivative adriamycin.

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