Intermediates for preparing pyrrolidinone derivatives

Details Intermediates for preparing pyrrolidinone derivatives Intermediates for preparing pyrrolidinone derivatives

C - Chemistry, Metallurgy

07

D

260/315.1, 260/4

C07D 235/02 (2006.01) C07D 207/273 (2006.01) C07D 233/32 (2006.01)

Patent

CA 1256883

ABSTRACT OF THE DISCLOSURE: Pyrrolidinone derivatives of general formula (1): Image (1) in which R is hydrogen, alkyl or acyl are useful in restoring cognitive function, in animals and man, when damaged by certain pathologies. In a process for preparing these derivatives a compound of general formula (2): Image (2) wherein R1 is hydrogen and R2 is benzyl or R1 and R2 together form a group Image , where R4 and R5 are independently hydrogen, alkyl, phenyl or together are 1,4- butylene or 1,5-pentylene; R3 is hydrogen or straight or branched alkyl of 1 to 4 carbon atoms; and X is alkyl is subjected to N-deprotection to give a compound of structure (2) where R1 and R2 both are hydrogen. This deprotected intermediate is then subjected to cyclisation to form the derivative (1). The deprotected intermediates can be isolated as acid-addition salts.

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