C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/238, 260/246
C07D 241/04 (2006.01) C07D 211/46 (2006.01) C07D 295/20 (2006.01) C07D 295/205 (2006.01) C07D 403/06 (2006.01) A61K 31/495 (2006.01) C07D 295/00 (2006.01)
Patent
CA 1237128
ABSTRACT Intermediates which are 1-piperazinecarboxylates or the general formula I Image (I) wherein R2, R3, R4, R5 are groups independently selected from hydrogen, lower alkyl having from 1 to 3 carbon atoms and phenyl, R6 is a group selected from hydrogen, F, C1, Br, lower alkoxy having from 1 to 3 carbon atoms and -CF3- -groups, R1 represents either an unsubstituted or substitu- ted aryl group with good leaving group properties, suitably a phenyl or a para-nitro-phenyl group-, for producing 1-piperazinecarboxamides of the general formula II Image (II) wherein R7 and R8 are groups independently selected from the group of hydrogen, alkyl straight or branched chains having from 1 to 10 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, aralkyl having from 7 to 9 carbon atoms, alkenyl having from 3 to 10 carbon atoms or R7 and R8 represents together with the adjacent nitrogen atom a 4-7 membered ring such as Image wherein m = 0, 1, 2, 3, n = 1 or 2, and Ra is a group selected from lower alkyl having from 1 to 3 carbon atoms, hydroxy-loweralkyl having from 2 to 4 carbon atoms and a lower alkanoyl having from 1 to 3 carbon atoms, A process for preparing the carboxamides of formula II by reacting the 1-piperazinecarboxylates of formula I with an amine of formula III Image (III) wherein R7 and R8 are as defined above, is also described.
454658
Abramo Aina L.
Bjork Anders K.k.
Fex Tomas
Ab Ferrosan
Biovitrum Ab
Smart & Biggar
LandOfFree
Intermediates for preparing substituted 1-piperazine-... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Intermediates for preparing substituted 1-piperazine-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates for preparing substituted 1-piperazine-... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1271911