Intermediates for the production of epipodophyllotoxin and...

Details Intermediates for the production of epipodophyllotoxin and... Intermediates for the production of epipodophyllotoxin and...

C - Chemistry, Metallurgy

07

D

260/311.1, 260/3

C07D 317/70 (2006.01) C07C 51/347 (2006.01) C07C 51/353 (2006.01) C07C 51/367 (2006.01) C07C 51/377 (2006.01) C07C 62/32 (2006.01) C07C 62/34 (2006.01) C07D 261/20 (2006.01) C07D 307/92 (2006.01) C07D 493/04 (2006.01) C07D 498/04 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1275651

ABSTRACT There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllo- toxin compounds of the general formula Image wherein R1 and R2 each are independently hydrogen or (lower)- alkoxy, or R1 and R2, taken together, is methylenedioxy; R4 and R6 each are independently hydrogen or (lower)alkoxy; and R5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.

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