Intermediates in preparation of new...

C - Chemistry – Metallurgy – 07 – C

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C07C 211/30 (2006.01) C07C 62/14 (2006.01) C07C 209/44 (2006.01) C07C 213/02 (2006.01) C07C 215/30 (2006.01) C07C 215/64 (2006.01) C07C 217/70 (2006.01) C07C 217/74 (2006.01) C07C 219/28 (2006.01) C07C 235/34 (2006.01) C07C 235/40 (2006.01)

Patent

CA 2222658

66 Intermediates of formula (III) Image (III) are employed in the manufacture of new phenylethanolaminomethyltetralins of formula (I) Image (I) wherein - E represents hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, phenyl, nitro, halogen or trifluoromethyl, - L represents hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, phenyl, nitro, or halogen, or - E and L taken together represent a group -CH=CH-CH=CH- or - CH2-CH2-CH2-CH2-, and - G represents hydrogen, chloro, hydroxy or an -OG' group wherein G' represents a (C1-C4) alkyl group either unsubstituted or substituted with hydroxy, (C1-C4) alkoxy, (C1-C4) alkoxycarbonyl, carboxy, or (C3-C7) cycloalkyl; a (C3-C7) cycloalkyl group; or a (C2-C4) alkanoyl group; and salts thereof. Such compounds of formula I are active as intestinal motility modulating agents and intraocular hypertension lowering agents.

Des intermédiaires de formule (III) Image (III) sont employés dans la fabrication de nouvelles phényléthanolaminométhyltétralines de formule (I) Image (I) où E représente un hydrogène, un alkyle en C1-C4, un alcoxy en C1-C4, un phényle, un nitro, un halogène ou un trifluorométhyle, L représente un hydrogène, un alkyle en C1-C4, un alcoxy en C1-C4, un phényle, un nitro ou un halogène, ou E et L pris ensemble représentent un groupe -CH=CH-CH=CH- ou - CH2-CH2-CH2-CH2-, et G représente un hydrogène, un chlore, un hydroxy ou un groupe -OG' où G' représente un groupe alkyle en C1-C4 non substitué ou substitué par un hydroxy, un alcoxy en C1-C4, un alcoxycarbonyle en C1-C4, un carboxy ou un cycloalkyle en C3-C7; un groupe cycloalkyle en C3-C7; ou un groupe alcanoyle en C2-C4; et les sels de ces derniers. Ces composés de formule I sont actifs comme agents modulant la motilité intestinale et agents abaissant l'hypertension intraoculaire.

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