Intermediates in producing phenoxyacetic acid derivatives...

C - Chemistry – Metallurgy – 07 – C

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C07C 69/736 (2006.01) C07C 43/315 (2006.01) C07C 67/31 (2006.01) C07C 213/08 (2006.01) A61K 31/216 (2006.01) C07C 217/60 (2006.01)

Patent

CA 2494176

The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has .beta.3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates. (see formula I) (see formula X)

L'invention concerne des intermédiaires représentés par la formule générale suivante (I), etc. que l'on utilise dans la production de dérivés de l'acide phénoxyacétique représentés par la formule générale suivante (X) ou leurs sels pharmaceutiquement acceptables ayant un effet de stimulation du récepteur de la beta -adrénaline et que l'on utilise comme préventifs ou remèdes contre l'obésité, l'hyperglycémie, les maladies causées par des troubles entériques, la fréquence urinaire, l'incontinence urinaire, la dépression ou les calculs biliaires ; ainsi qu'un procédé de production de ces intermédiaires ; et un procédé d'utilisation desdits intermédiaires : (I), (X) dans lesquels R<1> et R<2> représentent de manière indépendante un alkyle inférieur.

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