Intermediates on the synthesis of 17...

Details Intermediates on the synthesis of 17... Intermediates on the synthesis of 17...

C - Chemistry, Metallurgy

07

J

C07J 43/00 (2006.01) C07J 9/00 (2006.01) C07J 41/00 (2006.01)

Patent

CA 2045865

18148 TITLE OF THE INVENTION NEW INTERMEDIATES IN THE SYNTHESIS OF 17.beta.-ACYL-3-CARBOXY-ANDROSTA-3,5-DIENES ABSTRACT OE THE INVENTION NEW INTERMEDIATES IN THE SYNTHESIS OF 17.beta.-ACYL-3-CARBOXY-ANDROSTA-3,5-DIENES, OF THE FORMULA: Image 8372/SCM110 18148 wherein R2 is 2-thlopyridyl, and R3 is C2-C4 alkoxycarbonyl, C1-C4, or trifluoromethylsulfonyloxy. The above compounds are useful inter- mediates in producing testosterone 5.alpha.-reductase inhibitors which are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.

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