Intermediates produced during the preparation of new...

Details Intermediates produced during the preparation of new... Intermediates produced during the preparation of new...

C - Chemistry, Metallurgy

07

K

530/5.02, 530/5.

C07K 5/02 (2006.01) C07K 7/02 (2006.01)

Patent

CA 1336738

Intermediates of formulas (V), (VI) and (VII): Image (V) Image (VI) Image (VII) wherein pL represents a protective group of the side-chain amino function, PG is a suitable protecting group of the guanidino function, P is a carboxyl protecting group, R3 may represent a group -OR2 wherein R2 is hydrogen or a hydro- carbyl radical, a group -OP wherein P is a carboxyl protecting group, or a grouping of formula (IV): Image (IV) wherein P is as defined above, and PI is a protective group of tyrosine hydroxyl function for the preparation of new retro-inverso analogs of thymopentin (TP5) of general formula RNH-gArg-mLys-Asp-R1 where R is hydrogen or an acyl radical, and R1 is an -OR2 group where R2 is as defined above.

616330

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