C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/111, 260/335
C07F 7/10 (2006.01)
Patent
CA 1340579
Disclosed is a compound of the formula: Image wherein R is -CH2CX=CH2, -CH2CH2S1(CH3)3, p-nitrobenzyl, or a conventional radical forming an ester which is hydrolyzed under physiological conditions; X is H or C1; R1 is a conventional silyl protecting group; and Image Z, X1 and X2 are taken together and are Image ; or Z, X1 and X2 are taken separately, X1 and X2 are each hydrogen, and Z is p-nitrophenyloxycarbonyl. The compound is useful for the synthesis of certain 6-(1-hydroxyethyl) 2-substituted penem antibiotics.
617088
O'neil Brian Thomas
Phillips Douglas
Limited Pfizer
Smart & Biggar
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