Intermittent claudication therapeutic drugs comprising...

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2329524

Therapeutic drugs for intermittent claudication, chronic arterial occlusive diseases, arteriosclerosis obliterans and thromboangiitis obliterans contain as active ingredients pyrroloazepine derivatives or pharmacologically acceptable salts thereof, represented by formula (I) wherein the dotted line indicates existence or non-existence of a bond; when the bond of the dotted line exists, X does not exist, and, when the bond of the dotted line does not exist, X represents a hydrogen atom, a hydroxy group or a group OR1 in which R1 represents a substituted or unsubstituted alkyl group; Y represents a linear or branched, substituted or unsubstituted alkyl group; Z1 and Z2 are the same or different and each independently represent a hydrogen atom, a hydroxy group or a halogen atom; and W represents a hydrogen atom or a methyl group.

L'invention concerne des médicaments pour le traitement de la claudication intermittente, les artériopathies oblitérantes, les artériosclérose oblitérantes et les thromboangéites oblitérantes. Lesdits médicaments contiennent des dérivés de pyrroloazépine ou des sels de ceux-ci, acceptables au plan pharmacologique, en tant que principes actifs, représentés par la formule (I). Dans ladite formule (I), la ligne pointillée signale l'existence ou l'absence de liaison ; lorsque ladite liaison existe, X n'existe pas, et, lorsque la liaison n'existe pas, X représente un atome d'hydrogène, un groupe hydroxy ou un groupe OR¿1? dans lequel R¿1? représente un groupe alkyle substitué ou non ; Y représente un groupe alkyle linéaire ou ramifié, substitué ou non ; Z¿1? et Z¿2? sont identiques ou différents et représentent chacun séparément un atome d'hydrogène, un groupe hydroxy ou un atome d'halogène ; et W représente un atome d'hydrogène ou un groupe méthyle.

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