Internalizing erbb2 antibodies

Details Internalizing erbb2 antibodies Internalizing erbb2 antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C07K 14/705 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2326377

This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.

L'invention porte sur de nouveaux anticorps d'internalisation à liaison ERBB2. Les anticorps, appelés F5 et C1, se lient spécifiquement à l'antigène c-erbB2 et, lors de la liaison, sont facilement internalisés dans la cellule supportant le marqueur c-erbB2. L'invention porte également sur des molécules chimères comprenant les anticorps F5 et/ou C1 liés à une ou plusieurs molécules effectrices.

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