C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 167/233
C07D 493/08 (2006.01) A61K 31/41 (2006.01) A61K 31/445 (2006.01) C07C 17/16 (2006.01) C07C 45/29 (2006.01)
Patent
CA 2012267
Interphenylene 7-oxabicycloheptane substituted prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula Image wherein m is 1, 2 or 3; n is 0, 1, 2, 3 or 4; Y is 0, vinyl or a single bond, with the proviso that when n is 0, Y is a single bond; R is CO2H, CO2alkali metal, CO2 lower alkyl, CH2OH, CONHSO2R3, CONHR3a or 5-tetrazolyl, with the proviso that when R is 5-tetrazolyl, n is other than 0; X is O, S or NH; R1 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, aralkyl, cycloalkyl, cyclo-alkylalkyl, saturated heterocycle, saturated heterocyclicalkyl, aromatic heterocycle, aromatic heterocyclicalkyl or amido; each optionally substituted with an alkyl, aryl, cycloalkyl, or cycloalkylalkyl; and R2 is hydrogen, lower alkyl, aryl, or aralkyl, or R1 and R2 together with the N to which they are linked form a 5- to 8- membered ring; R3 is lower alkyl, aryl or aralkyl and R3a is hydrogen, lower alkyl, aroyl or aralkyl.
E.r. Squibb & Sons Inc.
Misra Raj Narain
Osler Hoskin & Harcourt Llp
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