C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 49/00 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2395466
Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for which expression is statistically different between control and calorie restricted animals has demonstrated that specific genes are preferentially expressed during calorie restriction. Screening for interventions which produce the same expression profile will provide interventions that increase life span. In a further aspect, it has been discovered that test animals on a calorie restricted diet for a relatively short time have a similar gene expression profile to test animals which have been on a long term calorie restricted diet.
Une restriction calorique à long terme permet d'allonger l'espérance de vie. L'invention concerne des procédés d'identification d'interventions qui imitent les effets d'une restriction calorique. Une analyse approfondie de gènes pour lesquels l'expression est statistiquement différente entre un animal témoin et un animal privé de calories a montré que des gènes spécifiques sont préférentiellement exprimés lors d'une restriction calorique. L'identification d'interventions qui produisent le même profil d'expression, fournit des interventions qui augmentent l'espérance de vie. Dans un autre mode de réalisation, les recherches ont montré que les animaux test astreints à un régime privé de calories sur une durée relativement courte, possèdent un profil d'expression génique semblable aux animaux test astreints à un régime privé de calories sur une longue durée.
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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