C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2428382
The invention provides cDNAs which encode mammalian intestinal proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of colon disorders, particularly colon cancer, Crohn's disease, and ulcerative colitis. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
L'invention concerne des ADNc qui codent pour des protéines intestinales mammaliennes. Elle concerne aussi l'utilisation d'ADNc, de fragments, de compléments et de variants de ces ADNc et de protéines codées, de portions de protéines codées et d'anticorps pour le diagnostic et le traitement de troubles du colon, en particulier du cancer du colon, de la maladie de Crohn et de la colite ulcéreuse. Elle concerne enfin des vecteurs d'expression et des cellules hôtes destinés à la production de la protéine, ainsi qu'un système modèle transgénique.
Baughn Mariah R.
Krasnow Randi
Lasek Amy W.
Baughn Mariah R.
Incyte Genomics Inc.
Krasnow Randi
Lasek Amy W.
Smart & Biggar
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