Intrabodies with defined framework that is stable in a...

Details Intrabodies with defined framework that is stable in a... Intrabodies with defined framework that is stable in a...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 16/14 (2006.01) C07K 19/00 (2006.01) C12N 15/10 (2006.01) C12N 15/13 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2396534

A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies.

L'invention concerne un procédé d'isolation de régions de détermination complémentaire (CDR) dans charpente définie stable et soluble dans un environnement réducteur, ainsi que les scFv pouvant être ainsi obtenus. A partir des scFv à charpente définie, il est possible de générer une bibliothèque scFv, la charpente étant conservée au moins pendant qu'une CDR est randomisée. Ces bibliothèques, par exemple dans des cellules de levure, sont adaptées pour cribler des interactions anticorps/CDR ou des anticorps.

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