C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 48/00 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2304208
The present invention is directed to methods of altering the regulation of the immune system, e.g., by selectively targeting individual or classes of immunomodulatory receptor molecules (IRMs) on cells comprising transducing the cells with an intracellularly expressed antibody, or intrabody, against the IRMs. In a preferred embodiment the intrabody comprises a single chain antibody against an IRM, e.g, MHC-1 molecules.
La présente invention concerne des procédés d'altération de la régulation du système immunitaire, consistant par exemple, à cibler, de manière sélective, un individu ou des classes de molécules réceptrices immunomodulatrices (IRM) sur des cellules comprenant une transduction de ces cellules avec un anticorps exprimé intracellulairement, ou des anticorps contre les IRM. Selon un mode de réalisation préféré, l'intracorps comprend un anticorps à chaîne unique contre une IRM, par exemple des molécules MHC-1.
Marasco Wayne
Mhashilkar Abner
Dana-Farber Cancer Institute Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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