Intracellular antibodies

Details Intracellular antibodies Intracellular antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) G06F 19/18 (2011.01) G06F 19/22 (2011.01) C07K 16/00 (2006.01) C40B 30/02 (2006.01) C40B 40/10 (2006.01) C40B 50/06 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) G06F 17/00 (2006.01)

Patent

CA 2456121

A method of identifying at least one consensus sequence for an intracellular antibody (ICS) comprising the steps of: creating a database comprising sequences of validated intracellular antibodies (VIDA database) and aligning the sequences of validated intracellular antibodies according to Kabat; determining the frequency with which a particular amino acid occurs in each of the positions of the aligned antibodies; selecting a frequency threshold value (LP or consensus threshold) in the range from 70 % to 100 %; identifying the positions of the alignment at which the frequency of a particular amino acid is greater than or equal to the LP value; and identifying the most frequent amino acid, in the positions of said alignment.

Cette invention concerne une méthode d'identification d'au moins une séquence consensus pour un anticorps intracellulaire consistant à : créer une base de données comprenant des séquences d'anticorps et à aligner lesdites séquences selon Kabat; déterminer la fréquence à laquelle un acide aminé particulier se rencontre dans chacune des positions des anticorps alignés ; sélectionner une valeur de seuil de fréquence (LP ou seuil de consensus) dans la plage 70 %-100 %; identifier les positions d'alignement auxquelles la fréquence d'un acide aminé particulier est supérieure ou égale à la valeur LP; et identifier l'acide aminé le plus fréquemment rencontré dans les positions dedit alignement.

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