C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) C12N 5/07 (2010.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 1/107 (2006.01) C07K 5/00 (2006.01) C07K 5/11 (2006.01) C07K 7/00 (2006.01)
Patent
CA 2425610
The invention relates to a sequence of amino acids with the capacity to facilitate transport of an effector across a biological membrane. More specifically, the present invention relates to novel peptide transporter that specifically target certain cell types for the intracellular delivery of drugs and therapeutic agents, comprising at least one amino acid sequence selected from the group consisting of: a) (XmRXoRXn); b) (XmRRRXn); c) (XmRRXRXn); and d) (XmRXRRXn), wherein X is a non-basic amino acid; m is an integer from zero to fourteen; n is an integer, independent of m, between zero and fourteen; o is an integer, independent of m and n, between zero and five; and wherein said transporter peptide is capable of translocating across a biological membrane.
L'invention concerne une séquence d'acides aminés pouvant faciliter le transport d'un effecteur à travers une membrane biologique. De façon plus spécifique, la présente invention porte sur de nouveaux transporteurs de peptides qui ciblent de manière spécifique certains types de cellules pour la libération intracellulaire de médicaments et d'agents thérapeutiques.
Ridout & Maybee Llp
University Of Lausanne
Xigen Sa
LandOfFree
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