Intracellular delivery of macromolecules

A - Human Necessities – 61 – K

Patent

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A61K 9/127 (2006.01) F02B 75/02 (2006.01)

Patent

CA 2223788

An improved liposome and related methods for using the liposome to facilitate the delivery of an extracellular agent to the cytoplasm of a target cell are provided. The improved liposomes include a phagosomal membrane permeabilizer, such as a hemolysin.

L'invention concerne un liposome amélioré et les procédés connexes d'utilisation dudit liposome pour faciliter l'administration d'un agent extracellulaire au cytoplasme d'une cellule cible. Ces liposomes améliorés contiennent un agent, tel qu'une hémolysine, qui permet de perméabiliser la membrane du phagosome.

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