C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61P 19/00 (2006.01) C07K 14/155 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/48 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2517496
The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.
L'invention concerne des polypeptides de fusion comprenant des domaines de transduction de protéines et des polypeptides ostéoinductives ainsi que des procédés d'utilisation de ces polypeptides pour induire l'ostéogenèse et favoriser la synthèse de protéoglycanes. L'invention concerne aussi des peptides ostéoinductives qui ont démontré leur capacité d'induire la formation osseuse in vivo.
Boden Scott
Drapeau Susan
Marx Jeffrey
Titus Frances
Yoon Sanwook
Emory University
Medtronic Sofamor Danek
Smart & Biggar
Warsaw Orthopedic Inc.
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