Intracellular domain of the her-2/neu protein for prevention...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/71 (2006.01) C07K 14/82 (2006.01) C12N 9/12 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2216601

Compounds and compositions for eliciting or enhancing immune reactivity to HER- 2/neu protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2/neu oncogene is associated.

On décrit des composés et compositions servant à provoquer ou à stimuler la réponse immune à la protéine HER-2/neu. Ces composés comprennent des polypeptides et des molécules d'acide nucléique codant ces peptides. On peut utiliser ces composés pour la prévention ou le traitement de tumeurs malignes auxquelles est associé l'oncogène HER-2/neu.

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