Intracellular drug delivery improving liposome

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) A61K 47/34 (2006.01) A61K 47/44 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2578921

[PROBLEMS] To provide a drug delivery system which is retained in the circulating blood and enhances the efficacy of a drug in the target organ or cells. [MEANS FOR SOLVING PROBLEMS] A drug-containing liposome for therapeutic use which comprises a liposome prepared by employing polyethylene glycol cholesteryl ether as a part of a liposome-forming base and using this liposome- forming base. By further employing polyethylene glycol diacyl glycerol ester as a part of the liposome-forming base, a favorable drug efficacy can be obtained.

[PROBLÈMES] Fournir un système d'administration de médicaments qui est retenu dans le flux sanguin et qui améliore l'efficacité d'un médicament sur l'organe ou les cellules cibles. [MOYEN POUR RÉSOUDRE LES PROBLÈMES] L'invention concerne un liposome qui contient un médicament à usage thérapeutique, ledit liposome étant préparé en employant de l'éther de cholestéryle de polyéthylène glycol dans le cadre d'une base de formation de liposome, et en utilisant ladite base. En employant également un ester de diacylglycérol de polyéthylène glycol dans le cadre d'une base de formation de liposome, il est possible d'obtenir un médicament favorablement efficace.

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