Intracellular expression of carboxypeptidase g2 in enzyme...

Details Intracellular expression of carboxypeptidase g2 in enzyme... Intracellular expression of carboxypeptidase g2 in enzyme...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/195 (2006.01) A61K 31/70 (2006.01) A61K 38/48 (2006.01) A61K 47/48 (2006.01) C07K 14/71 (2006.01) C12N 9/12 (2006.01) C12N 9/48 (2006.01)

Patent

CA 2196052

The invention provides a two-component system for gene-directed enzyme prodrug therapy which comprises: (a) a vector which encodes a carboxypeptidase which is expressed within a cell; and (b) a prodrug which can be converted into an active drug by said carboxypeptidase, useful in the treatment of tumours.

Système à deux constituants pour une thérapie génique à base de promédicament et d'enzyme, comprenant: (a) un vecteur qui code une carboxypeptidase exprimée à l'intérieur d'une cellule et (b) un promédicament qui peut être converti en un médicament actif par ladite carboxypeptidase, utile dans le traitement des tumeurs.

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