Intracellular pharmaceutical targeting

Details Intracellular pharmaceutical targeting Intracellular pharmaceutical targeting

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2370004

A method and composition to target compounds into cells such as eosinophils. A ligand for a CCR-3 eosinophil surface receptor is provided under conditions to bind to the receptor and cause internalization of the ligand-CCR-3 complex. A compound, such as a drug in an active or inactive form, may be bound to the ligand and delivered to an intracellular site of the cell where it may subsequently become activated. The methods and compositions may be used to treat a variety of eosinophil-mediated disorders, for example, allergies.

L'invention concerne un procédé et une composition permettant de cibler des composés dans des cellules, tels que les polynucléaires éosinophiles. Un ligand pour un récepteur de surface de polynucléaires éosinophiles CCR-3 est prévu dans des conditions dans lesquelles il se lie au récepteur et induit l'internalisation du complexe ligand-CCR3. Un composé, tel qu'un médicament sous forme active ou inactive, peut être lié au ligand et libéré dans un site intracellulaire de la cellule où il peut devenir actif ultérieurement. Les procédés et compositions peuvent être utilisés pour le traitement de divers troubles à médiation éosinophiliquee, comme par exemple les allergies.

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