Intracellular production of hepatitis c e1 and e2 truncated...

Details Intracellular production of hepatitis c e1 and e2 truncated... Intracellular production of hepatitis c e1 and e2 truncated...

C - Chemistry, Metallurgy

07

K

C07K 14/18 (2006.01) A61K 39/29 (2006.01) C07K 1/22 (2006.01) C12N 15/40 (2006.01) G01N 33/50 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2288374

Methods for obtaining recombinantly produced, C-terminally truncated, E1 and E2 polypeptides from cell lysates are disclosed. The intracellularly expressed truncated molecules display improved biological properties as compared to their secreted counterparts.

On décrit des procédés qui permettent de produire des polypeptides E1 et E2 tronqués à leur extrémité C-terminale, obtenus par recombinaison à partir de lysats cellulaires. Les molécules tronquées exprimées au niveau intracellulaire présentent des propriétés biologiques améliorées par comparaison avec leurs homologues secrétées.

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