Intracellular sensitizers for sonodynamic therapy

Details Intracellular sensitizers for sonodynamic therapy Intracellular sensitizers for sonodynamic therapy

A - Human Necessities

61

K

A61K 41/00 (2006.01) A61K 49/00 (2006.01) A61K 49/22 (2006.01)

Patent

CA 2335808

Texaphyrins are selectively retained in diseased tissue cells. When exposed to low level, non-thermal sonodynamic agent such as ultrasound, the texaphyrin- incorporated cells are selectively destroyed. There is provided a method of sonodynamic therapy by administering an effective amount of an intracellular sensitizer to a mammal in need thereof and providing an effective amount of a sonodynamic agent.

Des texaphyrines sont retenues sélectivement dans des cellules de tissus malades. Lorsqu'elles sont exposées à un agent sonodynamique non-thermique, à faible niveau, par exemple, des ultrasons, les cellules renfermant de la texaphyrine sont détruites sélectivement. L'invention concerne un procédé de traitement sonodynamique consistant à administrer une quantité efficace d'un sensibiliseur intracellulaire à un mammifère en demande et à fournir une quantité efficace d'un agent sonodynamique.

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