C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 38/17 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2352286
The present invention provides a carrier for the delivery of molecules with biological function into both cellular and nuclear compartments. The carrier disclosed is heat shock protein 70 ("Hsp70"), or a fragment of Hsp70 as described herein, as a vehicle for directed, non-invasive delivery of molecules, such as proteins, peptides, or DNA, that may modulate cellular activity. The present invention also encompasses the use of Hsp70, or a fragment thereof, to modulate cellular activity, preferably to modulate nuclear activity in a cell or cells.
L'invention concerne un transporteur permettant d'introduire des molécules à fonction biologique dans les compartiments cellulaires et nucléaires. Ce transporteur est la protéine de choc thermique 70 ("Hsp70"), ou un fragment de cette protéine Hsp70, utilisée en tant que véhicule pour une administration dirigée et non effractive de molécules telles que protéines, peptides ou ADN, susceptibles de moduler l'activité cellulaire. L'invention concerne également l'utilisation de la protéine Hsp70, ou d'un fragment de cette dernière pour moduler l'activité cellulaire, et de préférence pour moduler l'activité du noyau dans une ou plusieurs cellules.
Fujihara Sheri M.
Nadler Steven G.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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