Intracoronary stents containing quinazolinone derivatives

Details Intracoronary stents containing quinazolinone derivatives Intracoronary stents containing quinazolinone derivatives

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 9/00 (2006.01) A61K 31/506 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01) A61F 2/06 (2006.01)

Patent

CA 2253362

The invention provides an intracoronary stent coated with a quinazolinone derivative of formula (I), wherein n is 1 or 2, R1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy; R2 is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy, and R3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl, and physiologically acceptable salts thereof, for preventing restenosis after angioplasty.

L'invention concerne un extenseur intracoronarien revêtu d'un dérivé quinazolinone de la formule (I), ou de sels de celui-ci, acceptables sur le plan physiologique. Dans cette formule, n vaut 1 ou 2, R¿1? est choisi dans le groupe constitué par hydrogène, halogène, nitro, benzo, alkyle inférieur, phényle et alcoxy inférieur, R¿2? est choisi dans le groupe constitué par hydroxy, acétoxy et alcoxy inférieur, et R¿3? est choisi dans le groupe constitué par hydrogène et alcénoxy-carbonyle inférieur. Ce dérivé sert à empêcher la resténose après une angioplastie.

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