Intradermal influenza vaccine

Details Intradermal influenza vaccine Intradermal influenza vaccine

A - Human Necessities

61

K

A61K 39/145 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2684699

The invention relates to virosome-based influenza vaccines for the manufacture of medicaments that are administered intradermally in humans. The invention provides (trivalent) compositions comprising low doses of hemagglutinin (HA) antigen in a virosomal preparation that fulfill the immune response standards with respect to seroconversion rates, GMT-fold increase and protection rates, for use in vaccination set-ups.

La présente invention concerne des vaccins contre la grippe à base de virosome, destinés à la fabrication de médicaments qui sont administrés par voie intradermique à des êtres humains. L'invention concerne des compositions (trivalentes) contenant de faibles doses d'antigène d'hémagglutinine (HA) dans une préparation virosomale, qui répondent aux normes de la réponse immune en matière de taux de séroconversion, d'augmentation de la moyenne géométrique des titres (MGT) et de taux de protection, en vue de leur utilisation pour des mises au point de vaccins.

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