Intraductal management of breast lesions involving...

Details Intraductal management of breast lesions involving... Intraductal management of breast lesions involving...

A - Human Necessities

61

M

A61M 31/00 (2006.01) A61K 51/04 (2006.01)

Patent

CA 2478330

The present invention relates to an apparatus and method for administering a radioactive tracer dye and an inhibitor compound into a breast duct of the breast and imaging the breast for breast lesions. The radioactive tracer dye may be Tc-99m sestamibi and the inhibitor compound may inhibit a P- glycoprotein pump in tumor cells. When the inhibitor compound inhibits the P- glycoprotein pump in tumor cells, the radioactive tracer dye may effectively accumulate in tumor cells and improve the sensitivity of nuclear imaging of breast lesions.

La présente invention concerne un dispositif et une méthode servant à introduire un traceur radioactif et un composé inhibiteur dans un canal galactophore et à obtenir une image du sein pour détecter des lésions mammaires. Le traceur radioactif utilisé peut être du sestamibi Tc-99m et le composé inhibiteur peut être conçu pour inhiber une glycoprotéine-P dans des cellules tumorales. Lorsque le composé inhibiteur inhibe la glycoprotéine-P dans les cellules tumorales, le traceur radioactif peut s'accumuler efficacement dans les cellules tumorales et augmenter la sensibilité de l'imagerie nucléaire des lésions mammaires.

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