Intramolecularly cross-linked subtilisin proteases having...

Details Intramolecularly cross-linked subtilisin proteases having... Intramolecularly cross-linked subtilisin proteases having...

C - Chemistry, Metallurgy

12

N

C12N 9/54 (2006.01) C11D 3/386 (2006.01)

Patent

CA 2379718

The present disclosure describes subtilisin proteases comprising an intramolecular cross-link, wherein the intramolecular cross-link comprises a covalent linkage between an amino acid of a first residue of the protease and an amino acid of a second residue of the protease. The protease have decreased immunogenicity relative to a parent protease. Accordingly, such proteases are suitable for use in several types of compositions including, but not limite to, laundry, dishes, hard surface, skin care, hair care, beauty care, oral care, and contact lens compositions.

La présente invention concerne des protéases de subtilisine comprenant une réticulation intermoléculaire. Cette réticulation intermoléculaire comprend une liaison covalente entre un amino acide provenant d'un premier résidu de cette protéase et un amino acide provenant d'un second résidu de cette protéase. Cette protéase présente un pouvoir antigénique diminué par rapport à une protéase parente. Ces protéases conviennent donc pour plusieurs types de compositions, notamment, mais la liste n'est pas exhaustive, des compositions de lavage des textiles, de la vaisselle, de surfaces dures, pour des soins cutanés, capillaires, des produits de beautés, des soins buccaux, et des compositions pour lentilles de contact.

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