Intramyocardial injection of autologous bone marrow

Details Intramyocardial injection of autologous bone marrow Intramyocardial injection of autologous bone marrow

A - Human Necessities

61

K

A61K 35/28 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/535 (2006.01) C12N 5/02 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2487410

Methods are provided for enhancing transfection efficiency of bone marrow cells by transfecting early attaching cells derived from bone marrow in culture. Methods are also provided for utilizing such early attaching cells derived from autologous bone marrow to deliver angiogenesis-promoting transgenes to a patient. The transfected early attaching cells are introduced into an ischemic tissue, such as the heart, to enhance formation of collateral blood vessels. Methods are also provided for treating ischemic muscle by co- administration of autologous bone marrow cells and RGTA, for example RGTA11.

L'invention concerne des procédés permettant de renforcer le rendement de transfection de cellules de moelle osseuse par transfection de cellules de fixation précoce dérivées de moelle osseuse en culture. L'invention concerne également l'utilisation de ces cellules dérivées de moelle osseuse autologue en vue d'administrer au patient des transgènes favorisant l'angiogenèse. Les cellules de fixation précoce tranfectées sont introduites dans un tissu ischémique, par exemple le coeur, afin de renforcer la formation de vaisseaux sanguins collatéraux. L'invention concerne en outre des procédés de traitement de muscle ischémique par co-administration de cellules de moelle osseuse et de RGTA, par exemple RGTA11.

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