Intranasal administration of active agents to the central...

Details Intranasal administration of active agents to the central... Intranasal administration of active agents to the central...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/34 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2598666

A method for delivering a polypeptide to the central nervous system of a mammal is provided. The method involves attaching the polypeptide to an antibody or an antibody fragment and administering the fusion polypeptide intranasally, for delivery to the central nervous system. Methods of treatment are also provided, where a therapeutically effective amount of the composition is delivered to the nasal cavity of a mammal.

Une méthode de largage d'un polypeptide dans le système nerveux central est décrite. Cette méthode consiste à fixer le polypeptide à un anticorps ou à un fragment d'anticorps et à administrer le polypeptide de fusion par voie intranasale, de manière qu'il soit largué dans le système nerveux central. Des méthodes de traitement dans lesquelles une dose efficace au plan thérapeutique de ladite composition est larguée dans la cavité nasale d'un mammifère, sont décrites.

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