A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 31/473 (2006.01) A61K 47/26 (2006.01) A61K 47/34 (2006.01) A61K 47/40 (2006.01)
Patent
CA 2705153
The present invention provides a liquid aqueous formulation for the intranasal administration of apomorphine, which comprises: (a) at least about 15 mg/ml of apomorphine; and (b) a solubilising agent selected from (i) at least one polyoxyethylene-polyoxypropylene copolymer (poloxamer); (ii) at least one cyclodextrin; and (iii) at least one cyclodextrin together with chitosan. The formulations of the invention can be used in the treatment/management of Parkinson's disease.
La présente invention concerne une formulation aqueuse liquide destinée à l'administration intranasale d'apomorphine et comprenant : (a) au moins 15 mg/ml environ d'apomorphine ; et (b) un agent de solubilisation choisi parmi (i) au moins un copolymère de polyoxyéthylène et polyoxypropylène (poloxamère) ; (ii) au moins une cyclodextrine ; et (iii) au moins une cyclodextrine combinée avec du chitosane. Les formulations de l'invention peuvent être utilisées dans le traitement/la prise en charge de la maladie de Parkinson.
Cheng Yu-Hui
Watts Peter
Archimedes Development Limited
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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