A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 31/46 (2006.01) A61K 47/32 (2006.01) A61P 1/00 (2006.01)
Patent
CA 2303132
The present invention relates to pharmaceutical formulations containing scopolamine. More particularly, the invention relates to an intranasal gel formulation including scopolamine hydrobromide in a pharmaceutically acceptable carrier, most preferably an intranasal gel, at a pH at or below about 4.0, preferably at or below about 3.5, and a salt concentration below about 200 mM, with the gel solution incorporating polyvinylalcohol as a gelling agent. The intranasal formulations are particularly useful for preventing and/or treating nausea and/or vomiting associated with, for example, motion sickness.
L'invention concerne des formulations pharmaceutiques contenant de la scopolamine, et plus particulièrement des formulations de gel intranasal comprenant du bromhydrate de scopolamine dans un excipient pharmaceutiquement acceptable, de préférence un gel intranasal. Cette formulation a un pH égal ou inférieur à environ 4,0, de préférence égal ou inférieur à 3,5 et une concentration en sel inférieure à environ 200 mM, et la solution de gel contient du poly[alcool de vinyle] comme agent gélifiant. Ces formulations intranasales sont particulièrement utiles pour la prévention et/ou le traitement des nausées et/ou des vomissements associés par exemple au mal des transports.
Achari Raja G.
Behl Charanjit R.
Chowhan Prafulla K.
de Meireles Jorge C.
Dua Ramneik
Borden Ladner Gervais Llp
Nastech Pharmaceutical Company Inc.
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