Intranasal vaccine for use against disease caused by...

Details Intranasal vaccine for use against disease caused by... Intranasal vaccine for use against disease caused by...

C - Chemistry, Metallurgy

07

K

C07K 14/245 (2006.01) A61K 9/72 (2006.01) A61K 39/108 (2006.01) A61P 1/12 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2629088

The invention relates to an intranasal peptide vaccine for use against infection caused by enterotoxigenic Escherichia coli (ETEC), containing a common linear protein epitope known as CLE which is recognised by serums of patients infected with the bacteria and which is associated with a mucosal adjuvant comprising cholera toxin subunit B, known as CTB. The invention relates to a peptide containing twenty amino acids, which is located in the linear sequence of the CFA/I fimbria of enterotoxigenic Escherichia coli.

La présente invention concerne un vaccin peptidique intranasal contre une infection causée par l'ETEC, contenant un épitope protéique linéaire commun désigné sous le nom de CLE, reconnu par le sérum de patients infectés par la bactérie, et associé à un adjuvant des muqueuses qui constitue la sous-unité B de la toxine du coléra désignée sous le nom de CTB. Il s'agit d'un peptide de vingt acides aminés localisés dans la séquence linéaire du fimbria CFA/I de l'Escherichia coli entérotoxigénique.

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