Intraocular implants of alpha-2 adrenergic receptor agonists...

A - Human Necessities – 61 – K

Patent

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A61K 9/00 (2006.01) A61K 31/498 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2565067

Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others or to improve vision in a normal eye.

L'invention concerne des implants intraoculaires biocompatibles comprenant un agoniste des récepteurs alpha-2 adrénergiques et un polymère associé audit agoniste, de manière à faciliter la libération dudit agoniste dans un oeil pendant une durée accrue. L'agoniste des récepteurs alpha-2 adrénergiques peut être associé à une matrice de polymères biodégradables, telle qu'une matrice de deux polymères biodégradables. Les implants peuvent être placés dans un oeil aux fins de traitement d'un ou de plusieurs états oculaires, tels qu'une vasculopathie oculaire ou un glaucome, parmi d'autres ou aux fins d'amélioration de la vision dans un oeil normal.

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